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J Cell Mol Med. 2007 Nov-Dec;11(6):1239-50. doi: 10.1111/j.1582-4934.2007.00127.x.

Tyrosine phosphorylation-dependence of caveolae-mediated endocytosis.

Author information

1
Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, College of Medicine at Chicago, Chicago, IL 60612, USA.

Abstract

Caveolae are flask-shaped plasma membrane invaginations that mediate endocytosis and transcytosis of plasma macromolecules, such as albumin, insulin and low-density lipoprotein (LDL), as well as certain viruses, bacteria and bacterial toxins. Caveolae-mediated transcytosis of macromolecules is critical for maintaining vascular homeostasis by regulating the oncotic pressure gradient and tissue delivery of drugs, vitamins, lipids and ions. Entrapment of cargo within caveolae induces activation of signalling cascades leading to caveolae fission and internalization. Activation of Src tyrosine kinase is an early and essential step that triggers detachment of loaded caveolae from the plasma membrane. In this review, we examine how Src-mediated phosphorylation regulates caveolae-mediated transport by orchestrating the localization and activity of essential proteins of the endocytic machinery to regulate caveolae formation and fission.

PMID:
18205698
PMCID:
PMC4401290
DOI:
10.1111/j.1582-4934.2007.00127.x
[Indexed for MEDLINE]
Free PMC Article

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