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Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S89-92. doi: 10.1007/s00259-007-0707-8.

In vivo imaging of axonal transport using MRI: aging and Alzheimer's disease.

Author information

1
Departments of Radiology and Bioengineering, University of Washington, 1959 N.E. Pacific Street,Seattle, WA 98195-7115, USA. minoshim@u.washington.edu

Abstract

PURPOSE:

MRI using manganese as a trans-synaptic axonal tracing agent can unveil dynamics of axonal transport in living subjects. We use this technology to test the hypotheses if impaired axonal transport is a significant pathophysiological process in aging and early Alzheimer's disease (AD) and in part accounting for "selective vulnerability" of projection neurons in AD.

METHODS:

To allow quantitative assessment of axonal transport in vivo, we developed voxel-based statistical mapping technology as well as a tracer kinetic modeling method based on mass transport for manganese-enhanced MRI to estimate axonal transport rates in aging rats and AD transgenic mice.

RESULTS:

These techniques demonstrated manganese-enhanced signal changes in axonal projections of the olfactory tract and decreased axonal transport rates in rodent models of aging and AD.

CONCLUSION:

Altered axonal transport may be a critical pathophysiological process in aging and AD. Manganese-enhanced MRI provides exciting opportunities for the investigations of altered axonal transport in AD and related disorders.

PMID:
18204931
DOI:
10.1007/s00259-007-0707-8
[Indexed for MEDLINE]

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