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J Neurol. 2008 Jan;255(1):112-6. doi: 10.1007/s00415-008-0713-1. Epub 2008 Jan 22.

Prolonged refractory status epilepticus with early and persistent restricted hippocampal signal MRI abnormality.

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Pediatric Intensive Care Unit, CHU BicĂȘtre, 78, rue du Gal Leclerc, 94275 Le Kremlin BicĂȘtre, France.


We report a series of four children with a prolonged refractory status epilepticus with an early persistent and restricted hippocampal signal MRI abnormality but otherwise no proven etiology. The mean duration of status epilepticus was 53 days (range, 20-91 days) with a mean length of stay in Pediatric Intensive Care Unit (PICU) of 2 months (range, 26-115 days). Neurological outcome showed epilepsy disease in all, and mild to severe disability. In long-term follow-up, the initial MRI signal abnormality developed into a cortical atrophy in all cases. The establishment of the diagnosis, etiology, and options for treatment are discussed.

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