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Nat Neurosci. 2008 Feb;11(2):131-3. doi: 10.1038/nn2038. Epub 2008 Jan 20.

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

Author information

1
Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

Abstract

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.

PMID:
18204444
DOI:
10.1038/nn2038
[Indexed for MEDLINE]

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