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Planta Med. 2008 Jan;74(1):55-60. doi: 10.1055/s-2007-993780. Epub 2008 Jan 17.

Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa.

Author information

1
Laboratoire de Pharmacognosie, CNRS FRE 2715, IFR53 Biomolécules, Université de Reims Champagne-Ardenne, Reims, France.

Abstract

Through a bioassay-guided phytochemical investigation involving mushroom tyrosinase inhibitory activity, seven farnesyl diglycosides ( 1 - 7), five flavonoids ( 8 - 12), one trimeric proanthocyanidin ( 13), two triterpenes ( 14 and 15), and one cerebroside ( 16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G ( 1 - 3) were new acyclic sesquiterpene diglycosides. The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin ( 14), lupeol ( 15) and soyacerebroside I ( 16) demonstrated a potent tyrosinase inhibitory activity.

PMID:
18203056
DOI:
10.1055/s-2007-993780
[Indexed for MEDLINE]

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