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Planta Med. 2008 Jan;74(1):69-72. doi: 10.1055/s-2007-993783. Epub 2008 Jan 17.

Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales.

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1
Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand.

Abstract

Five metabolites, ( Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3-methylsulfanylpiperazine-2,5-dione ( 1), (3S,3'R)-3-(3'-hydroxybutyl)-7-methoxyphthalide ( 2), ( S)-3-butyl-7-methoxyphthalide ( 3), (3R,6R)-bisdethiodi(methylthio)hyalodendrin ( 4), and bis- N-norgliovictin ( 5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1, 3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 microg/mL.

PMID:
18203053
DOI:
10.1055/s-2007-993783
[Indexed for MEDLINE]
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