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Cell Mol Life Sci. 2008 Apr;65(7-8):1133-49. doi: 10.1007/s00018-008-7472-0.

The magic of the hypoxia-signaling cascade.

Author information

1
CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, Nice, France.

Abstract

All organisms respond to changes in their environment by activating complex signaling cascades. The "hypoxia-signaling cascade" is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.

PMID:
18202826
DOI:
10.1007/s00018-008-7472-0
[Indexed for MEDLINE]

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