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Genetics. 2008 Jan;178(1):609-10. doi: 10.1534/genetics.107.074609.

Naive application of permutation testing leads to inflated type I error rates.

Author information

1
The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

Abstract

Failure to account for family structure within populations or in complex mating designs via uninformed applications of permutation testing will lead to inflated type I error rates. Careful consideration of the design factors is essential since some situations allow several valid permutation strategies, and the choice that maximizes statistical power will not always be intuitive.

PMID:
18202402
PMCID:
PMC2206111
DOI:
10.1534/genetics.107.074609
[Indexed for MEDLINE]
Free PMC Article

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