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Neuroimage. 2008 Apr 1;40(2):932-939. doi: 10.1016/j.neuroimage.2007.12.002. Epub 2007 Dec 15.

Narrative speech production: an fMRI study using continuous arterial spin labeling.

Author information

1
Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
2
Department of Neurology - 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283, USA. Electronic address: mgrossma@mail.med.upenn.edu.

Abstract

Functional magnetic resonance imaging (fMRI) with continuous arterial spin labeling (CASL) was employed to monitor brain activation during narrative production of a semi-structured speech sample in healthy young adults. Subjects were asked to describe a wordless children's picture story. Significant activations were found in bilateral prefrontal and left temporal-parietal regions during narrative production relative to description of a single picture and relative to viewing the wordless picture story while producing a nonsense word. We conclude that inferior frontal cortex serves as a top-down organizational resource for narrative production and demonstrate the feasibility of collecting extended speech samples using CASL perfusion fMRI.

PMID:
18201906
PMCID:
PMC2291537
DOI:
10.1016/j.neuroimage.2007.12.002
[Indexed for MEDLINE]
Free PMC Article

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