Format

Send to

Choose Destination
See comment in PubMed Commons below
J Mol Biol. 2008 Feb 29;376(4):913-25. doi: 10.1016/j.jmb.2007.11.074. Epub 2007 Dec 4.

Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?

Author information

1
Lady Davis Institute for Medical Research, 3755, Côte Sainte-Catherine, Montreal, Quebec, Canada. volker.blank@mcgill.ca

Abstract

The small Maf basic leucine zipper (bZIP) proteins MafF, MafG and MafK, while modest in size, have emerged as crucial regulators of mammalian gene expression. Intriguingly, small Mafs do not contain an obvious transcriptional activation domain. However, previously perceived as "mere" partner molecules conferring DNA binding specificity to complexes with larger bZIP proteins, such as the CNC family member Nrf2, it has become clear that small Maf proteins are essential and dynamically regulated transcription factors. Current data suggest stringent control of small Maf protein function through transcriptional and post-translational mechanisms. Initial gene targeting experiments revealed considerable functional redundancy among small Maf proteins in vivo. This was not unexpected, due to the high level of homology among the three small Mafs. Nevertheless, further studies showed that these transcription factors have critical roles in various cellular processes, including stress signaling, hematopoiesis, CNS function and oncogenesis. Recent data provide a possible link between small Maf-mediated transcription and the inflammatory response.

PMID:
18201722
DOI:
10.1016/j.jmb.2007.11.074
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center