Format

Send to

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2008 Jan 21;14(3):390-400.

Immunopathogenesis of inflammatory bowel disease.

Author information

1
Cedars-Sinai Inflammatory Bowel Disease Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

Abstract

Crohn's disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn's disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis.

PMID:
18200661
PMCID:
PMC2679127
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Support Center