Format

Send to

Choose Destination
Immunity. 2008 Jan;28(1):1-4. doi: 10.1016/j.immuni.2007.12.008.

Genetic background and the dilemma of translating mouse studies to humans.

Author information

1
Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. juan_rivera@nih.gov

Abstract

C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.

PMID:
18199409
DOI:
10.1016/j.immuni.2007.12.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center