Format

Send to

Choose Destination
See comment in PubMed Commons below
Int Braz J Urol. 2007 Nov-Dec;33(6):785-90; discussion 790-4.

Cavernous body reduction in four patients with erectile dysfunction due to insufficient venous occlusion and a deficit of elastic fibers in the tunica albuginea.

Author information

1
Section of Urology, School of Medicine, University of Naples Federico II, Naples, Italy.

Abstract

INTRODUCTION:

The corpora cavernosa are cylindrical vessels containing fluid under pressure. Thus, if cavernous wall resistance decreases, the radius increases and internal pressure decreases (LaPlace's law). We reasoned that if we decrease the corpus cavernosum radius, by excising a strip from each tunica albuginea, intracavernous pressure would increase during erection.

MATERIALS AND METHODS:

We treated with this procedure, four patients (mean age 41.5) with long-standing erectile dysfunction due to veno-occlusive dysfunction, non-responders to phosphodiesterase-5 inhibitors and intracavernous PGE1 injection.

RESULTS:

Two months post-surgery, intracavernous PGE1 (40 mcg) induced a satisfactory erection in two patients and a 45% and 58% tumescence in the other two. PGE1 responders also responded to 100 mg sildenafil. After 100 mg sildenafil and 20 mg tadalafil, the two non-responders had erections that enabled penetration but were short lasting.

CONCLUSION:

The procedure described could be more effective than cavernous revascularization operations. The results seem to confirm the mathematical assumptions.

PMID:
18199346
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for International Braz J Urol
    Loading ...
    Support Center