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Chem Soc Rev. 2008 Feb;37(2):320-30. doi: 10.1039/b610213c. Epub 2007 Dec 13.

Fluorine in medicinal chemistry.

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1
The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA.

Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

PMID:
18197348
DOI:
10.1039/b610213c
[Indexed for MEDLINE]

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