Format

Send to

Choose Destination
See comment in PubMed Commons below
Environ Health Perspect. 2008 Jan;116(1):57-63. doi: 10.1289/ehp.10049.

Exogenous and endogenous determinants of blood trihalomethane levels after showering.

Author information

1
National Center for Environmental Health, Centers for Disease Control and Prevention, Chamblee, GA 30341, USA. lfb9@cdc.gov <lfb9@cdc.gov>

Abstract

BACKGROUND:

We previously conducted a study to assess whether household exposures to tap water increased an individual's internal dose of trihalomethanes (THMs). Increases in blood THM levels among subjects who showered or bathed were variable, with increased levels tending to cluster in two groups.

OBJECTIVES:

Our goal was to assess the importance of personal characteristics, previous exposures, genetic polymorphisms, and environmental exposures in determining THM concentrations in blood after showering.

METHODS:

One hundred study participants completed a health symptom questionnaire, a 48-hr food and water consumption diary, and took a 10-min shower in a controlled setting. We examined THM levels in blood samples collected at baseline and 10 and 30 min after the shower. We assessed the significance of personal characteristics, previous exposures to THMs, and specific gene polymorphisms in predicting postshower blood THM concentrations.

RESULTS:

We did not observe the clustering of blood THM concentrations observed in our earlier study. We found that environmental THM concentrations were important predictors of blood THM concentrations immediately after showering. For example, the chloroform concentration in the shower stall air was the most important predictor of blood chloroform levels 10 min after the shower (p < 0.001). Personal characteristics, previous exposures to THMs, and specific polymorphisms in CYP2D6 and GSTT1 genes were significant predictors of both baseline and postshowering blood THM concentrations as well as of changes in THM concentrations associated with showering.

CONCLUSION:

The inclusion of information about individual physiologic characteristics and environmental measurements would be valuable in future studies to assess human health effects from exposures to THMs in tap water.

KEYWORDS:

CYP2D6; CYP2E1; GSTT1; disinfection by-products; drinking water disinfection; showering exposures; trihalomethanes

PMID:
18197300
PMCID:
PMC2199304
DOI:
10.1289/ehp.10049
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for National Institute of Environmental Health Sciences Icon for PubMed Central
    Loading ...
    Support Center