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Cell Cycle. 2008 Jan 1;7(1):7-10. Epub 2007 Oct 15.

HDAC6 a new cellular stress surveillance factor.

Author information

1
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland.

Abstract

Less than a decade has passed since HDAC6 was first identified and regarded as an unusual histone deacetylase harbouring two catalytic domains. Early demonstration of its cytoplasmic localisation, its ubiquitin-binding and its tubulin-deacetylase activities took HDAC6 far away from everything known to involve other histone-deacetylases. Recent discoveries confirmed the very unique functions of HDAC6 among deacetylases and pointed to this protein as a master regulator of cell response to cytotoxic assaults. HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses.

PMID:
18196966
DOI:
10.4161/cc.7.1.5186
[Indexed for MEDLINE]
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