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J Zhejiang Univ Sci B. 2008 Jan;9(1):16-21. doi: 10.1631/jzus.B071605.

A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.

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1
Department of Chem-Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

Abstract

Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich's ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.

PMID:
18196608
PMCID:
PMC2170464
DOI:
10.1631/jzus.B071605
[Indexed for MEDLINE]
Free PMC Article
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