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Kidney Int. 2008 Feb;73(3):251-3. doi: 10.1038/sj.ki.5002695.

Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney disease.

Author information

1
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Ben-Cowley@ouhsc.edu

Abstract

Low intracellular calcium, present in untreated polycystic kidney epithelia, results in a proliferative response to cyclic adenosine monophosphate. Treatment with a calcium channel blocker (CCB) caused exacerbation of autosomal dominant polycystic kidney disease in rats. Data regarding use of CCBs in human polycystic kidney disease (PKD) are limited and mixed. Thus, it is premature to extrapolate these findings to human PKD.

PMID:
18195694
DOI:
10.1038/sj.ki.5002695
[Indexed for MEDLINE]
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