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Carbohydr Res. 2008 Mar 17;343(4):651-9. doi: 10.1016/j.carres.2007.12.011. Epub 2008 Jan 14.

Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey.

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Chemistry Department, University of Waikato, Private Bag 3105, Hamilton, New Zealand.

Erratum in

  • Carbohydr Res. 2009 Dec 14;344(18):2609.


Using HPLC a fraction of New Zealand manuka honey has been isolated, which gives rise to the non-peroxide antibacterial activity. This fraction proved to be methylglyoxal, a highly reactive precursor in the formation of advanced glycation endproducts (AGEs). Methylglyoxal concentrations in 49 manuka and 34 non-manuka honey samples were determined using a direct detection method and compared with values obtained using standard o-phenylenediamine derivatisation. Concentrations obtained using both the methods were similar and varied from 38 to 828 mg/kg.

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