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Dev Cell. 2008 Jan;14(1):4-6. doi: 10.1016/j.devcel.2007.12.014.

Retromer retrieves wntless.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse-108, Dresden 01307, Germany. eaton@mpi-cbg.de

Abstract

Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.

PMID:
18194646
DOI:
10.1016/j.devcel.2007.12.014
[Indexed for MEDLINE]
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