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Headache. 2008 Feb;48(2):284-6. doi: 10.1111/j.1526-4610.2007.01016.x. Epub 2008 Jan 8.

Memantine and NMDA antagonism for chronic migraine: a potentially novel therapeutic approach?

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Department of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.


We present the case of a woman with chronic migraine who unexpectedly reported full remission of headache after memantine, an NMDA receptor antagonist, was administered for treating concomitant mild cognitive impairment. An underlying dose-dependent effect of memantine on headache symptoms in chronic daily headache and chronic migraine could be assumed.

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[Indexed for MEDLINE]

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