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Immunology. 2008 Jul;124(3):388-400. doi: 10.1111/j.1365-2567.2007.02787.x. Epub 2008 Jan 11.

Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants.

Author information

1
Medical Research Council Laboratories Gambia, Banjul, The Gambia. djcm1@liverpool.ac.uk

Abstract

Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and the consequent T-cell differentiation in Gambian infants was associated with impaired specific responses to measles vaccination or polyclonal responses to the superantigen staphylococcal enterotoxin B (SEB). While the concentration of undifferentiated (CD27(+) CD28(+) CCR7(+)) T-cells in peripheral blood was unaffected by CMV, there was a large increase in differentiated (CD28(-) CD57(+)) CD8 T-cells and a smaller increase in differentiated CD4 cells. One week post-vaccination, the CD4 cell interferon-gamma (IFN-gamma) response to measles was lower among CMV-infected infants, but there were no other differences between the cytokine responses, or between the cytokine or proliferative responses 4 months post-vaccination. However, the CD8 T cells of CMV-infected infants proliferated more in response to SEB and the antibody response to measles correlated with the IFN-gamma response to CMV, indicating that CMV infection actually enhances some immune responses in infancy.

PMID:
18194268
PMCID:
PMC2440833
DOI:
10.1111/j.1365-2567.2007.02787.x
[Indexed for MEDLINE]
Free PMC Article

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