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Chromosoma. 2008 Jun;117(3):235-42. doi: 10.1007/s00412-007-0144-2. Epub 2008 Jan 10.

Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks.

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Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.


Telomere caps prevent chromosome ends from being recognized as DNA double-strand breaks (DSBs). Unlike most organisms studied, the telomere-capping function of Drosophila does not require a specific sequence. Without this sequence component, Drosophila telomeres most resemble DNA breaks and, thus, represent a simpler system for the study of telomere capping. I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance.

[Indexed for MEDLINE]

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