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Cell Mol Life Sci. 2008 Apr;65(7-8):1186-201. doi: 10.1007/s00018-007-7492-1.

Biology-inspired synthesis of compound libraries.

Author information

1
Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, Dortmund, Germany.

Abstract

Biologically active small molecules represent the basis for chemical biology applications in which small molecules are used as chemical tools to probe biological processes. In this report, we review two approaches to design and synthesize compound libraries for biological screenings, i.e., diversity-oriented synthesis (DOS) and biology-oriented synthesis (BIOS).

PMID:
18193390
DOI:
10.1007/s00018-007-7492-1
[Indexed for MEDLINE]

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