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Nat Genet. 2008 Feb;40(2):149-51. doi: 10.1038/ng.2007.61. Epub 2008 Jan 13.

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

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1
National Heart and Lung Institute, Imperial College London, UK. j.scott@imperial.ac.uk

Abstract

We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.

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PMID:
18193046
DOI:
10.1038/ng.2007.61
[Indexed for MEDLINE]

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