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Am J Geriatr Psychiatry. 2008 Feb;16(2):145-55. doi: 10.1097/JGP.0b013e318157caec. Epub 2008 Jan 11.

Depressive symptom trajectories and associated risks among bereaved Alzheimer disease caregivers.

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  • 1Center for Psycho-oncology and Palliative Care Research, Dana Farber Cancer Institute, Boston, MA 02115, USA.



A recent study concluded that depressive symptoms among caregivers decline on average from before to after the Alzheimer disease (AD) patient's death. The present study sought to determine if subgroups of bereaved AD caregivers follow distinctive depressive symptom trajectories and the characteristics associated with membership in depressive symptom subgroups.


Latent class mixture models sought to identify clusters of homogeneous participants in the Resources for Enhancing Alzheimer's Caregiver Health study-a multisite, randomized caregiver intervention trial.


One hundred eighty-two community-based bereaved caregivers were included in the study.


The Center for Epidemiologic Studies Depression Scale assessed depressive symptoms among the AD caregivers at baseline and three follow-up visits.


Three postloss depressive symptom trajectories emerged: persistently syndromal depression (N = 30, 16.5%); syndromal-becoming-threshold level depression (N = 62, 34.0%); and persistently absent depression (N = 90, 49.5%). Lower income, higher preloss depression levels, greater caregiver behavioral burden, less family support, and adverse health behaviors (e.g., smoking, skipped meals, and lack of exercise) after loss were risk factors for syndromal and syndromal-becoming-threshold level depression after loss.


Early intervention to reduce caregiving behavioral burden and enhance family support and promote healthier behaviors of bereaved AD caregivers may decrease the risk of syndromal or syndromal-becoming-threshold level depression after loss.

[PubMed - indexed for MEDLINE]
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