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Trends Genet. 2008 Feb;24(2):94-101. doi: 10.1016/j.tig.2007.11.009. Epub 2008 Jan 14.

Tissue development and RNA control: "HOW" is it coordinated?

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1
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. lgvolk@weizmann.ac.il

Abstract

The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.

PMID:
18192064
DOI:
10.1016/j.tig.2007.11.009
[Indexed for MEDLINE]
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