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Vaccine. 2008 Feb 6;26(6):762-8. doi: 10.1016/j.vaccine.2007.11.091. Epub 2007 Dec 26.

Willingness of Chinese injection drug users to participate in HIV vaccine trials.

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1
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), 27 Nanwei Road, Xuanwu District, Beijing 100050, China.

Abstract

BACKGROUND:

Chinese injection drug users (IDUs) may be a proper candidate population for HIV vaccine trials.

OBJECTIVE:

To evaluate willingness to participate (WTP) in HIV vaccine trials among Chinese IDUs.

METHODS:

Questionnaire interviews were completed among 401 IDUs in Urumqi City in northwestern China in 2005.

RESULTS:

Overall 74.3% of participants said that they would be definitely willing to participate in HIV vaccine trials, 17.7% were probably willing, 6.2% were probably not willing, and remaining 1.8% were definitely not willing to join. Multivariate logistic regression analysis demonstrated that WTP was positively associated with having ever had sex with a drug use partner (adjusted odds ratio [AOR]: 1.8; 95% confidence interval [CI]: 1.04, 3.2), sharing needle and syringe with a new drug use partner in the past 3 months (AOR: 3.8; 95% CI: 1.2, 11.7), perceived family support for participation (AOR: 7.4; 95% CI: 4.3, 12.7), and perceived vaccine protection against HIV infection (AOR: 16.1; 95% CI: 3.7, 70.8), and was negatively associated with perceived risk of social stigma and isolation for participation (AOR: 0.3; 95% CI: 0.2, 0.5).

CONCLUSIONS:

The stated WTP in hypothetical HIV vaccine trials was high among Chinese IDUs. Further studies are needed to evaluate actual enrollment into the trials.

PMID:
18191881
PMCID:
PMC2762822
DOI:
10.1016/j.vaccine.2007.11.091
[Indexed for MEDLINE]
Free PMC Article
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