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Am J Obstet Gynecol. 2008 Mar;198(3):325.e1-6. doi: 10.1016/j.ajog.2007.09.047. Epub 2008 Jan 14.

Maternal microchimerism in human fetal tissues.

Author information

1
Department of Obstetrics and Gynecology, the Center for Fetal Medicine, Karolinska University Hospital, Huddinge, Sweden. anna.jonsson@karolinska.se

Abstract

OBJECTIVE:

The aim of the present study was to analyze the presence of maternal cells in human fetal tissues in the second trimester.

STUDY DESIGN:

Tissues from 11 second-trimester fetuses terminated because of social reasons or because of malformations and/or trisomy were investigated. By cell sorting and polymerase chain reaction amplification, we studied the presence of maternal CD3+, CD19+, CD34+, and CD45+ in different fetal tissues and in placenta.

RESULTS:

In the group of fetuses with normal karyotype and normal autopsy findings, 4 of 5 fetuses were positive for maternal microchimerism. In the group in which the fetuses were diagnosed with trisomy 21 and/or malformations, we found cells of maternal origin in 3 of 6 fetuses.

CONCLUSION:

The results from this study indicate that maternal microchimerism is a common phenomenon in the second-trimester fetuses. Maternal cells of lymphoid and myeloid lineages and hematopoietic progenitors are widely distributed in the second-trimester fetuses.

PMID:
18191801
DOI:
10.1016/j.ajog.2007.09.047
[Indexed for MEDLINE]

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