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Clin Biochem. 2008 Apr;41(6):375-80. doi: 10.1016/j.clinbiochem.2007.12.008. Epub 2007 Dec 27.

Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease.

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1
Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

Abstract

OBJECTIVES:

Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor.

DESIGN AND METHODS:

For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters.

RESULTS:

A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin.

CONCLUSIONS:

This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor.

[Indexed for MEDLINE]

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