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Trends Microbiol. 2008 Feb;16(2):44-7. doi: 10.1016/j.tim.2007.12.004. Epub 2008 Jan 10.

New (fluorescent) light on poliovirus entry.

Author information

1
Division of Infectious Diseases, Children's Hospital of Philadelphia, Abramson Research Center 1202E, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. bergelson@email.chop.edu

Abstract

To initiate infection, poliovirus must release its RNA genome into the cytoplasm of a target cell, a process called 'uncoating'. How this occurs has remained uncertain, despite studies over several decades. Two new studies re-address the question of poliovirus entry. The results suggest that poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process.

PMID:
18191571
PMCID:
PMC2527862
DOI:
10.1016/j.tim.2007.12.004
[Indexed for MEDLINE]
Free PMC Article
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