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Cell. 2008 Jan 11;132(1):24-6. doi: 10.1016/j.cell.2007.12.017.

How IRE1 reacts to ER stress.

Author information

1
Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. ron@saturn.med.nyu.edu

Abstract

The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell (Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.

PMID:
18191217
DOI:
10.1016/j.cell.2007.12.017
[Indexed for MEDLINE]
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