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Int J Lab Hematol. 2009 Apr;31(2):236-40. doi: 10.1111/j.1751-553X.2007.01023.x. Epub 2008 Jan 7.

Auer rod-like intracytoplasmic inclusions in multiple myeloma. A case report and review of the literature.

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Medizinische Klinik III, Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.


Several intracytoplasmic morphological changes in the plasma cells of multiple myeloma have been described previously. However, Auer rod-like inclusions are rarely found in these types of cells. Here, we report a case of multiple myeloma with Auer rod-like, needle-shaped intracytoplasmic inclusions in plasma cells. A review of all published cases revealed that this phenomenon is exclusively found in myeloma with kappa-type paraprotein. The nature of these intracellular inclusions and the relationship to prognostic implications and concomitant illnesses are discussed.

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