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Adv Exp Med Biol. 2008;613:313-9. doi: 10.1007/978-0-387-74904-4_36.

Gamma-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE.

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Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77550, USA.


In conclusion, gamma-secretase is expressed in both retinal microvascular endothelial cells and RPE cells and is able to elicit regulated intramembrane proteolysis of VEGFR1. Furthermore, gamma-secretase regulates the translocation of the intracellular domain of VEGFR1 as well as full length VEGFR1 in both cell types. Gamma-secretase is clearly able to act as a potent negative regulators of VEGFR2 induced in vitro angiogenesis but its role in the RPE has yet to be elucidated. We conclude that gamma-secretase may offer a therapeutic target for the treatment of both retinal and choroidal neovascularization.

[Indexed for MEDLINE]

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