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Bioorg Med Chem Lett. 2008 Feb 15;18(4):1507-10. doi: 10.1016/j.bmcl.2007.12.061. Epub 2007 Dec 27.

Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance.

Author information

1
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Abstract

Three sets of novel 4-deoxy-l-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-l-arabinose (l-Ara4N). One compound diminished the transfer of l-Ara4N onto lipid A. These results suggest that small molecules might be designed that would effect the same reversal of bacterial resistance observed in genetic knockouts.

PMID:
18187325
PMCID:
PMC2516481
DOI:
10.1016/j.bmcl.2007.12.061
[Indexed for MEDLINE]
Free PMC Article

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