Format

Send to

Choose Destination
Curr Opin Biotechnol. 2008 Feb;19(1):41-9. doi: 10.1016/j.copbio.2007.11.007. Epub 2008 Jan 9.

Experimental validation for quantitative protein network models.

Author information

1
Molecular Translational Technology, Molecular Therapeutics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 1126B, 9000 Rockville Pike, Bethesda, MD 20892, USA. nishizus@mail.nih.gov

Abstract

Cellular responses are the consequence of complex reactions of protein networks. The complexity should ultimately be described by a set of formulas in a quantitative fashion, in which each formula defines the reactions in response to given types of input. However, testing these formulas has not been a simple task because of the lack of appropriate means for experimental validation. 'Reverse-phase' lysate microarrays have been proved to be powerful for such requirements and thus can be a good resource for providing an experimental reference point for the theoretical biology of protein networks.

PMID:
18187317
DOI:
10.1016/j.copbio.2007.11.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center