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Curr Opin Biotechnol. 2008 Feb;19(1):41-9. doi: 10.1016/j.copbio.2007.11.007. Epub 2008 Jan 9.

Experimental validation for quantitative protein network models.

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Molecular Translational Technology, Molecular Therapeutics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 1126B, 9000 Rockville Pike, Bethesda, MD 20892, USA.


Cellular responses are the consequence of complex reactions of protein networks. The complexity should ultimately be described by a set of formulas in a quantitative fashion, in which each formula defines the reactions in response to given types of input. However, testing these formulas has not been a simple task because of the lack of appropriate means for experimental validation. 'Reverse-phase' lysate microarrays have been proved to be powerful for such requirements and thus can be a good resource for providing an experimental reference point for the theoretical biology of protein networks.

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