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Annu Rev Med. 2008;59:473-85. doi: 10.1146/annurev.med.59.081906.081110.

The challenge of hepatitis C in the HIV-infected person.

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1
Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

Hepatitis C virus (HCV) coinfection occurs in an estimated one quarter of HIV-infected persons in Europe, Australia, and the United States. As use of highly active antiretroviral drugs has markedly reduced opportunistic infections, HCV-related liver disease has emerged as a leading cause of death. HIV infection adversely affects both the natural history and the treatment of hepatitis C. Because there are no experimental models of coinfection and because the pathogenesis of each infection is incompletely understood, how HIV infection alters hepatitis C is not clear. This review considers the epidemiology, natural history, treatment, and pathogenesis of hepatitis C in HIV-infected persons.

[Indexed for MEDLINE]

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