Send to

Choose Destination
Structure. 2008 Jan;16(1):62-71. doi: 10.1016/j.str.2007.11.008.

Force generation in kinesin hinges on cover-neck bundle formation.

Author information

Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.

Erratum in

  • Structure. 2008 Jul;16(7):1147.


In kinesin motors, a fundamental question concerns the mechanism by which ATP binding generates the force required for walking. Analysis of available structures combined with molecular dynamics simulations demonstrates that the conformational change of the neck linker involves the nine-residue-long N-terminal region, the cover strand, as an element that is essential for force generation. Upon ATP binding, it forms a beta sheet with the neck linker, the cover-neck bundle, which induces the forward motion of the neck linker, followed by a latch-type binding to the motor head. The estimated stall force and anisotropic response to external loads calculated from the model agree with force-clamp measurements. The proposed mechanism for force generation by the cover-neck bundle formation appears to apply to several kinesin families. It also elucidates the design principle of kinesin as the smallest known processive motor.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center