Format

Send to

Choose Destination
Neuron. 2008 Jan 10;57(1):3-4. doi: 10.1016/j.neuron.2007.12.017.

From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis.

Author information

1
Department of Anatomy and Developmental Biology, University College London, University Street, London WC1E 6BT, UK.

Abstract

Electrical activity plays a crucial role in neuronal circuit assembly. Activation of NMDA receptors induces the elevation of intracellular calcium, resulting in the modulation of calcium-calmodulin-dependent protein kinases (CaMKs). The CaMK pathway regulates synaptogenesis by driving the formation of dendritic spines. However, the molecular effectors downstream of this pathway have remained poorly defined. In this issue of Neuron, Saneyoshi et al. identify a new signaling complex containing CaMKK/CaMKI/betaPIX/Rac that regulates the morphogenesis of spines in an activity-dependent manner.

PMID:
18184558
PMCID:
PMC5405797
DOI:
10.1016/j.neuron.2007.12.017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center