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J Pediatr Endocrinol Metab. 2007 Nov;20(11):1241-8.

Pamidronate treatment of hypercalcemia caused by vitamin D toxicity.

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Division of Pediatric Endocrinology, Schneider Children's Hospital, New Hyde Park, NY 11040, USA.


We present a 16 month-old previously healthy boy with refractory hypercalcemia due to an overdose of an over-the-counter vitamin supplement. The patient presented to the emergency department with a few weeks' history of irritability, constipation and intermittent vomiting. His serum calcium was found to be 18 mg/dl. He was first treated with intravenous fluids, furosemide and glucocorticoids without significant improvement, but became eucalcemic within 24 hours after receiving a single dose of pamidronate. This case highlights the potential danger of high dose vitamin supplements in children, and the salutary effects of treatment with bisphosphonate.

[Indexed for MEDLINE]

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