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Dermatology. 2008;216(3):205-12. doi: 10.1159/000112927. Epub 2008 Jan 9.

Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features: analysis of the parallel pattern.

Author information

1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. kimotoma@1998.jukuin.keio.ac.jp

Abstract

BACKGROUND:

Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns.

AIM:

To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy.

METHODS:

A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed.

RESULTS:

Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion.

CONCLUSION:

Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.

PMID:
18182811
DOI:
10.1159/000112927
[Indexed for MEDLINE]

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