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Trends Parasitol. 2008 Feb;24(2):89-95. doi: 10.1016/j.pt.2007.12.001. Epub 2008 Jan 7.

Genomics of reproduction in nematodes: prospects for parasite intervention?

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1
Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, UK. Alasdair.Nisbet@moredun.ac.uk

Abstract

Understanding reproductive processes in parasitic nematodes has the potential to lead to the informed design of new anthelmintics and control strategies. Little is known, however, about the molecular mechanisms underlying sex determination, gametogenesis and reproductive physiology for most parasitic nematodes. Together with comparative analyses of data for the free-living nematode Caenorhabditis elegans, molecular investigations are beginning to provide insights into the processes involved in reproduction and development in parasitic nematodes. Here, we review recent developments, focusing on technological aspects and on molecules associated with sex-specific differences in adult nematodes.

PMID:
18182326
DOI:
10.1016/j.pt.2007.12.001
[Indexed for MEDLINE]
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