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Curr Opin Cell Biol. 2008 Feb;20(1):53-63. doi: 10.1016/j.ceb.2007.11.005. Epub 2008 Jan 7.

Kinetochore-microtubule interactions: the means to the end.

Author information

1
Wellcome Trust Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee, MSI/WTB/JBC Complex, Dundee, UK. t.tanaka@lifesci.dundee.ac.uk

Abstract

Kinetochores are proteinaceous complexes containing dozens of components; they are assembled at centromeric DNA regions and provide the major microtubule attachment site on chromosomes during cell division. Recent studies have defined the kinetochore components comprising the direct interface with spindle microtubules, primarily through structural and functional analysis of the Ndc80 and Dam1 complexes. These studies have facilitated our understanding of how kinetochores remain attached to the end of dynamic microtubules and how proper orientation of a kinetochore-microtubule attachment is promoted on the mitotic spindle. In this article, we review these recent studies and summarize their key findings.

PMID:
18182282
PMCID:
PMC2358929
DOI:
10.1016/j.ceb.2007.11.005
[Indexed for MEDLINE]
Free PMC Article

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