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Int Immunopharmacol. 2008 Feb;8(2):135-42. doi: 10.1016/j.intimp.2007.08.003. Epub 2007 Aug 17.

Participation of kallikrein-kinin system in different pathologies.

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1
Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. claudio@fmrp.usp.br <claudio@fmrp.usp.br>

Abstract

The general description of kinins refers to these peptides as molecules involved in vascular tone regulation and inflammation. Nevertheless, in the last years a series of evidences has shown that local hormonal systems, such as the kallikrein-kinin system, may be differently regulated and are of pivotal importance to pathophysiological control. The combined interpretations of many recent studies allow us to conclude that the kallikrein-kinin system plays broader and richer roles than those classically described until recently. In this review, we report findings concerning the participation of the kallikrein-kinin system in inflammation, cancer, and in pathologies related to cardiovascular, renal and central nervous systems.

PMID:
18182216
DOI:
10.1016/j.intimp.2007.08.003
[Indexed for MEDLINE]
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