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J Cell Biol. 2008 Jan 14;180(1):13-5. doi: 10.1083/jcb.200712098. Epub 2008 Jan 7.

Being there: cellular targeting of voltage-gated sodium channels in the heart.

Author information

1
Howard Hughes Medical Institute, Durham, NC 27710, USA. v.bennett@cellbio.duke.edu

Abstract

Voltage-gated sodium (Na(v)) channels in cardiomyocytes are localized in specialized membrane domains that optimize their functions in propagating action potentials across cell junctions and in stimulating voltage-gated calcium channels located in T tubules. Mutation of the ankyrin-binding site of Na(v)1.5, the principal Na(v) channel in the heart, was previously known to cause cardiac arrhythmia and the retention of Na(v)1.5 in an intracellular compartment in cardiomyocytes. Conclusive evidence is now provided that direct interaction between Na(v)1.5 and ankyrin-G is necessary for the expression of Na(v)1.5 at the cardiomyocyte cell surface.

PMID:
18180365
PMCID:
PMC2213601
DOI:
10.1083/jcb.200712098
[Indexed for MEDLINE]
Free PMC Article

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