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Int Wound J. 2008 Mar;5(1):20-5. doi: 10.1111/j.1742-481X.2007.00349.x. Epub 2008 Jan 3.

The use of marrow-derived stem cells to accelerate healing in chronic wounds.

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Amputation Prevention Center, Broadlawns Medical Center, Des Moines, IA, USA.


Adult bone marrow-derived stem cells may aid the healing of chronic lower extremity wounds by transplanting a population of progenitor cells locally into the wound. We present results from three cases in which bone marrow aspirate containing marrow-derived cells was applied/injected locally into complex lower extremity chronic wounds of differing aetiologies. Our case series suggest that bone marrow aspirate, applied topically and injected into the wound periphery, may be a useful and potentially safe adjunct to wound simplification and ultimate closure.

[Indexed for MEDLINE]

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