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Cytokine. 2008 Feb;41(2):92-104. doi: 10.1016/j.cyto.2007.11.013. Epub 2008 Jan 4.

Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.

Author information

1
Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.

Abstract

IL-17 is the defining cytokine of a newly-described "Th17" population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its function or molecular biology. However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, which will be reviewed here.

PMID:
18178098
PMCID:
PMC2667118
DOI:
10.1016/j.cyto.2007.11.013
[Indexed for MEDLINE]
Free PMC Article

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