Format

Send to

Choose Destination
Curr Opin Cell Biol. 2008 Feb;20(1):101-6. doi: 10.1016/j.ceb.2007.11.004. Epub 2008 Jan 4.

Structural and regulatory roles of nonmotor spindle proteins.

Author information

1
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. amity.l.manning@dartmouth.edu

Abstract

Chromosome alignment and segregation during cell division rely on a highly ordered bipolar microtubule array called the mitotic spindle. The organization of microtubules into bipolar spindles with focused poles during mitosis requires numerous microtubule-associated proteins including both motor and nonmotor proteins. Nonmotor microtubule-associated proteins display extraordinary diversity in how they contribute to mitotic spindle organization. These mechanisms include regulation of microtubule nucleation and organization, direct and indirect influences on motor function, and control of cell cycle progression. Furthermore, many nonmotor spindle proteins display altered expression in cancer cells emphasizing their important roles in cell proliferation.

PMID:
18178073
PMCID:
PMC2289991
DOI:
10.1016/j.ceb.2007.11.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center