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Behav Brain Res. 2008 Apr 9;188(2):416-9. doi: 10.1016/j.bbr.2007.11.017. Epub 2007 Nov 29.

Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats.

Author information

1
Schizophrenia Research Institute (SRI), Sydney, Australia. tmdb66@uow.edu.au

Abstract

Perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. This study examined the effects of perinatal PCP treatment on behaviour of adult rats in holeboard, elevated plus maze, social interaction and forced swim tests. PCP-treated rats displayed hyperactivity in the holeboard and forced swim tests. These persistent behavioural changes are relevant to the study of psychiatric disorders such as schizophrenia.

PMID:
18177952
DOI:
10.1016/j.bbr.2007.11.017
[Indexed for MEDLINE]

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