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Am J Obstet Gynecol. 2008 Apr;198(4):399.e1-5. doi: 10.1016/j.ajog.2007.10.784. Epub 2008 Feb 21.

No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission.

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1
Department of Obstetrics and Gynecology and Epidemiology, Columbia University, New York, NY 10032, USA. ktc10@columbia.edu

Abstract

OBJECTIVE:

The purpose of this study was to assess the risk of perinatal HIV-1 transmission in women who are coinfected with herpes simplex virus-2 (HSV-2).

STUDY DESIGN:

We performed a nested case-control study of 26 women whose HIV-1 was transmitted to their infants and 52 control subjects whose HIV-1 was not transmitted. We assessed antepartum serologic evidence of HSV-2 by HSV-2 serostatus and genital tract evidence of HSV-2 by presence of HSV-2 DNA.

RESULTS:

There was no significant association between antepartum serologic evidence of HSV-2 coinfection and the risk of perinatal HIV-1 transmission. There was also no association between antepartum genital tract evidence of HSV-2 coinfection and risk of perinatal HIV-1 transmission.

CONCLUSION:

Women who were infected with HIV-1 with antepartum serologic and genital tract evidence of HSV-2 coinfection did not appear to have an increased risk of perinatal HIV-1 transmission. However, further investigations are needed to assess HSV-2 reactivation and the risk of perinatal HIV-1 transmission at the time of delivery.

PMID:
18177832
DOI:
10.1016/j.ajog.2007.10.784
[Indexed for MEDLINE]
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